2,3,4,6,8-Pentahydroxy-1-methylxanthone

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
2,3,4,6,8-Pentahydroxy-1-methylxanthone

2,3,4,6,8-Pentahydroxy-1-methylxanthone 是 Wardomyces anomalus 的山酮衍生物。2,3,4,6,8-Pentahydroxy-1-methylxanthone 具有显著的抗氧化活性。2,3,4,6,8-Pentahydroxy-1-methylxanthone 是 p56^lck 酪氨酸激酶抑制剂。2,3,4,6,8-Pentahydroxy-1-methylxanthone 能够用于治疗心血管疾病的研究。

2,3,4,6,8-Pentahydroxy-1-methylxanthone Chemical Structure

CAS No. : 548740-87-0

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2,3,4,6,8-Pentahydroxy-1-methylxanthone 相关产品

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生物活性

2,3,4,6,8-Pentahydroxy-1-methylxanthone is a xanthone derivative of Wardomyces anomalus. 2,3,4,6,8-Pentahydroxy-1-methylxanthone shows significant antioxidant activities. 2,3,4,6,8-Pentahydroxy-1-methylxanthone is inhibitors of p56^lck tyrosine kinase. 2,3,4,6,8-Pentahydroxy-1-methylxanthone can be used to treat cardiovascular disease^[1].

IC₅₀ & Target

p56 ^lck^[1]

体外研究
(In Vitro)

2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM, 50µg/mL ox-LDL, 6h) 在人脐静脉内皮细胞对 ox-LDL 诱导的细胞凋亡具有保护作用^[2]。
2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM, 50µg/mL ox-LDL, 6h) 在人脐静脉内皮细胞抑制 ox-LDL 诱导的 VECs粘附分子表达^[2]。
2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM, 50µg/mL ox-LDL, 6h) 在人脐静脉内皮细胞对ox-LDL 引起的氧化损伤有保护作用^[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

2,3,4,6,8-Pentahydroxy-1-methylxanthone 相关抗体:

Apoptosis Analysis^[2]

Cell Line:	Human umbilical vein endothelial cells
Concentration:	1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time:	6h
Result:	The percentage of apoptosis cells significantly decreased to around 20 ~ 40%.

Western Blot Analysis^[2]

Cell Line:	Human umbilical vein endothelial cells
Concentration:	1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time:	6h
Result:	The level of pro-apoptotic protein Bax decreased significantly, while that of anti-apoptotic protein Bcl-2 increased significantly.

Apoptosis Analysis^[2]

Cell Line:	Human umbilical vein endothelial cells
Concentration:	1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time:	6h
Result:	The protein level of VCAM-1 and ICAM-1 decreased.

Immunofluorescence^[2]

Cell Line:	Human umbilical vein endothelial cells
Concentration:	1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
Incubation Time:	6h
Result:	Activated Nrf2 nuclear translocations and the expression of HO-1 was significantly increased.

分子量

290.23

Formula

C₁₄H₁₀O₇

CAS 号

548740-87-0

结构分类

Flavonoids
Other Flavonoids

初始来源

海洋天然产物
海洋微生物

微生物

Arthrinium sp.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Abdel-Lateff A, et al. Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. J Nat Prod. 2003 May;66(5):706-8. [Content Brief]

[2]. Hou JR, et al. Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells. Mar Drugs. 2021 Dec 18;19(12):712. [Content Brief]

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