Thiomarinol A (Synonyms: 4-Hydroxythiomarinol C)

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Thiomarinol A  (Synonyms: 4-Hydroxythiomarinol C)

Thiomarinol A (4-Hydroxythiomarinol C) 是一种有效的抗生素。Thiomarinol A 是二硫代吡咯酮和海藻酸的混合物。Thiomarinol A 显示出抗菌活性。Thiomarinol A 以剂量依赖性方式抑制 MRSA IleRS，Kiapp 值为 19 nM。

Thiomarinol A (Synonyms: 4-Hydroxythiomarinol C)

Thiomarinol A Chemical Structure

CAS No. : 146697-04-3

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生物活性

Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1].

体外研究
(In Vitro)

Thiomarinol A shows antimicrobial activity with MICs of 0.002, 0.08, 0.04, 0.04, 0.50, 0.02, 0.01 µM for COL IleRS, LLMR COL IleRSV588F/V631F, LLMR COL IleRSF587V/V631F, LLMR COL IleRSV588F, IleRSV588F MupA, thiomarinol-resistant COL IleRSG593D, thiomarinol-resistant COL IleRSP606S, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Thiomarinol A 相关抗体:
分子量

640.81

Formula

C30H44N2O9S2
CAS 号

146697-04-3
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

A. rava
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (524 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Johnson RA, et al. Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. J Am Chem Soc. 2021 Aug 11;143(31):12003-12013.  [Content Brief]

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