10,11-Dehydrocurvularin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
10,11-Dehydrocurvularin  纯度: ≥99.0%

10,11-Dehydrocurvularin 是一种常见的真菌毒素和抗生素。10,11-Dehydrocurvularin 是热休克反应的强激活剂。10,11-Dehydrocurvularin 抑制 TGF-β 信号通路。抗肿瘤活性

10,11-Dehydrocurvularin

10,11-Dehydrocurvularin Chemical Structure

CAS No. : 21178-57-4

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生物活性

10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

分子量

290.31

Formula

C16H18O5
CAS 号

21178-57-4
性状

固体

颜色

Off-white to light yellow

结构分类
  • Antibiotics
  • Disease Research
  • Anticancer
  • Phenols
  • Polyphenols
  • Antibiotics
  • Macrolide Antibiotics
初始来源
  • 微生物

Aspergillus terreus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (529 KB) SDS (251 KB)

COA (175 KB) RP-HPLC (1156 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.  [Content Brief]

    [2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.  [Content Brief]

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