Virginiamycin S1

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Virginiamycin S1 

Virginiamycin S1 是环状十六肽抗生素，由弗氏链霉菌 (Streptomyces virginiae) 产生, 在氨酰基-tRNA 结合和肽键形成的水平上抑制细菌蛋白质合成，对多种革兰氏阳性菌显示出强大的杀菌活性。Virginiamycin S1 属于链阳性菌属家族中的 B 型化合物，与链阳性菌属家族中的 A 型化合物Virginiamycin M1 协同用于多药耐药性细菌感染。

Virginiamycin S1

Virginiamycin S1 Chemical Structure

CAS No. : 23152-29-6

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生物活性

Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections[1][2].

分子量

823.89

Formula

C43H49N7O10
CAS 号

23152-29-6
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Macrolide Antibiotics
初始来源
  • 微生物

Streptomyces virginiae
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (549 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Ningsih F, et al. VisG is essential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine. Microbiology. 2011 Nov;157(Pt 11):3213-20.  [Content Brief]

    [2]. Ge B, et al. Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae. Sci Rep. 2017 Sep 8;7(1):11017.  [Content Brief]

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