Cajanin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Cajanin 

Cajanin 是一种有效且具有口服活性的 抗黑色素 剂。Cajanin 在 MNT1 细胞中显示出抗增殖活性。Cajanin 有效降低黑色素含量。Cajanin 下调 MITF、酪氨酸酶、TRP-1 和 Dct (TRP-2) 的 mRNA 和蛋白质表达水平。Cajanin 诱导细胞周期停滞在 G2/M 和 S 期。Cajanin 刺激成骨细胞增殖。Cajanin 具有研究人类色素沉着过度症和更年期骨质疏松症的潜力。

Cajanin

Cajanin Chemical Structure

CAS No. : 32884-36-9

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Cajanin 相关产品

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生物活性

Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis[1][2].

体外研究
(In Vitro)

Cajanin shows strong mitogenic as well as differentiation-promoting effects on osteoblasts[2].
Cajanin induces the phosphorylation of both Erk1/2 and Akt[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cajanin 相关抗体:
体内研究
(In Vivo)

Cajanin (10 mg/kg, p.o.; daily for 30 consecutive days) increases the BMD levels in all anatomical regions of the skeleton studied in Sprague Dawley rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

300.26

Formula

C16H12O6
CAS 号

32884-36-9
结构分类
  • Flavonoids
  • Isoflavones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 其他科
  • 红色海藻
  • 植物
  • 豆科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Netcharoensirisuk P, et al. Cajanin Suppresses Melanin Synthesis through Modulating MITF in Human Melanin-Producing Cells. Molecules. 2021 Oct 5;26(19):6040.  [Content Brief]

    [2]. Bhargavan B, et al. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem. 2009 Oct 1;108(2):388-99.  [Content Brief]

    [3]. Wensaas AJ, et al. Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid. Diabetes. 2009 Mar;58(3):527-35.  [Content Brief]

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