4”,5”-Dehydroisopsoralidin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
4”,5”-Dehydroisopsoralidin 

4”,5”-Dehydroisopsoralidin 是一种 β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂(IC50: 6.3 μM)。4”,5”-Dehydroisopsoralidin 具有抗炎和抗氧化作用。4”,5”-Dehydroisopsoralidin 可用于炎症和癌症的研究。

4

4”,5”-Dehydroisopsoralidin Chemical Structure

CAS No. : 65639-51-2

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4”,5”-Dehydroisopsoralidin 相关产品

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生物活性

4”,5”-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM). 4”,5”-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4”,5”-Dehydroisopsoralidin can be used in the research of inflammation and cancners[1][2].

IC50 & Target

β-glucuronidase[1]
体外研究
(In Vitro)

4”,5”-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC50 value of 6.3 μM[1].
4”,5”-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC50: >50 μM) to H4IIE, HCT116, C6 cells[2].
4”,5”-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay)[2].
4”,5”-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan in P. corylifolia (MEP assay)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

4”,5”-Dehydroisopsoralidin 相关抗体:
分子量

334.32

Formula

C20H14O5
CAS 号

65639-51-2
结构分类
  • Phenylpropanoids
  • Coumarins
初始来源
  • 植物
  • 茄科
  • 白英
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (530 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. De-Wu Zhang, et al. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J Nat Med. 2012 Apr;66(2):362-6.  [Content Brief]

    [2]. Christian Limper, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65(9):1393-408.  [Content Brief]

    [3]. Tong-Hong Wang, et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat Commun. 2022 Mar 9;13(1):1238.  [Content Brief]

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