Pectic acid (Synonyms: Methyl protopectin; Polygalacturonic acid)

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Pectic acid  (Synonyms: Methyl protopectin; Polygalacturonic acid)

Pectic acid (Methyl protopectin) 是一种聚半乳糖醛酸，可诱导垂体肿瘤细胞凋亡 (apoptosis) 和坏死 (necrosis)。Pectic acid 可用于癌症和自身免疫性疾病的研究。

Pectic acid (Synonyms: Methyl protopectin; Polygalacturonic acid)

Pectic acid Chemical Structure

CAS No. : 9046-40-6

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生物活性

Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease[2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells[1].
Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining[2].
Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner[2].
Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Pectic acid 相关抗体:

Cell Cycle Analysis[2]

Cell Line: GH3/B6 cells
Concentration: 1 mg/mL
Incubation Time: 24 h
Result: Induced sub G1 events, and DNA fragmentation, which was correlated with the number of the apoptotic cells.

体内研究
(In Vivo)

Pectic acid (25 and 100 mg/kg, oral gavage) increases colon length, downregulates disease activity index, histopathological score and proinflammatory cytokine levels in Ulcerative colitis (UC) mice[3].
Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ulcerative colitis (UC) mice[3]
Dosage: 25, 100 mg/kg
Administration: Oral gavage
Result: Exhibited the longest colon, lowest DAI, and minimum histopathological score.
Decreased the proinflammatory cytokines in the colonic tissue of UC mice.
Animal Model: Ulcerative colitis (UC) mice[3]
Dosage: 6.25, 12.5 mg/kg
Administration: Intravenous injection
Result: Decreased the spleen and thymus index.
Restored the Th17/Treg balance in the spleen and lamina propria of UC mice.
Improved the gut microbiota composition.

CAS 号

9046-40-6
结构分类
  • Saccharides
  • Polysaccharides
  • Others
初始来源
  • 植物
  • 芸香科
  • 柑橘
  • 内源性代谢物
  • 人肠道微生物代谢物
  • 微生物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Delaram Eslimi, et al. Pectic acid effects on prolactin secretion in GH3/B6 rat pituitary cell line. Iran Biomed J. 2008 Jul;12(3):167-72.  [Content Brief]

    [2]. Farnoosh Attari, et al. Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells. Iran Biomed J. 2009 Oct;13(4):229-36.  [Content Brief]

    [3]. Jie Song, et al. Effects of oral administration and intravenous injection of polygalacturonic acid on the immunomodulation and gut microbiota in UC mice. Int J Biol Macromol. 2022 Sep 30;217:150-160.  [Content Brief]

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