Polyketomycin

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Polyketomycin 

Polyketomycin 是一种从链霉菌属中分离的四环醌糖苷抗生素。Polyketomycin 抑制革兰氏阳性细菌 (Gram-positive bacteria) 的生长，其 MIC 值小于 0.2 µg/mL。Polyketomycin 具有抗菌，抗癌，抗疟疾的作用。

Polyketomycin

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

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Polyketomycin 相关产品

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生物活性

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50 & Target[1][2]

Plasmodium

 

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Polyketomycin 相关抗体:
体内研究
(In Vivo)

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

864.84

Formula

C44H48O18
CAS 号

200625-47-4
结构分类
  • Quinones
  • Naphthalene Quinones
  • Phenols
  • Polyphenols
初始来源
  • 微生物

Streptomyces sp. MK277-AF1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (530 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5.  [Content Brief]

    [2]. Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83.  [Content Brief]

    [3]. Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4.  [Content Brief]

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