Dihydrocapsiate

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Dihydrocapsiate  纯度: 99.18%

Dihydrocapsiate 作为二氢 capsinoid 家族的化合物，是一种口服活性 TRPV1 激动剂。Dihydrocapsiate 可用于代谢疾病的研究。

Dihydrocapsiate

Dihydrocapsiate Chemical Structure

CAS No. : 205687-03-2

规格 价格 是否有货 数量
1 mg ￥1636 In-stock
5 mg ￥3600 In-stock
10 mg ￥5900 In-stock
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生物活性

Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease[1].

IC50 & Target[1]

TRPV1

 

体外研究
(In Vitro)

Dihydrocapsiate (10, 25 and 50 μM; 48 hours; human preadipocytes) does not affect cell viability[1].
Dihydrocapsiate (10 and 20 μM; 8 days; mature adipocytes) markedly decreases the expression levels of other adipogenic markers (such as SREBP1, FABP4, PLIN1, ADIPOQ and LEPTIN) and inflammatory markers (MCP1 and TNFα), whereas it enhances the expression levels of PGC1α (master regulator of mitochondrial biogenesis) and TBX1 (marker of “brite” cell) [1].
Dihydrocapsiate (25~200 μM; RAW 264.7 cells) prevents NO release and intracellular ROS generation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrocapsiate 相关抗体:

Cell Viability Assay[1]

Cell Line: Human preadipocytes
Concentration: 10, 25 and 50 μM
Incubation Time: 48 hours
Result: Did not affect cell viability.

RT-PCR[1]

Cell Line: Mature adipocytes
Concentration: 10 and 20 μM
Incubation Time: 8 days
Result: Markedly decreased the expression levels of other adipogenic markers (such as SREBP1, FABP4, PLIN1, ADIPOQ and LEPTIN) and inflammatory markers (MCP1 and TNFα), whereas it enhanced the expression levels of PGC1α (master regulator of mitochondrial biogenesis) and TBX1 (marker of “brite” cell).

体内研究
(In Vivo)

Dihydrocapsiate (2 and 10 mg/kg; p.o.) improves morphometric parameters and insulin levels, prevents high fat diet (HFD)-induced adipocyte size and enhances energy expenditure-related genes in WAT, alleviates HFD-induced hepatic steatosis, prevents HFD-induced fat deposition and enhances mitochondrial biogenesis genes in BAT and improves intestinal morphology and modulates SCFA availability.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-fed mice[1]
Dosage: 2 and 10 mg/kg
Administration: P.o.
Result: Improved morphometric parameters and insulin levels, prevented HFD-induced adipocyte size and enhanced energy expenditure-related genes in WAT, alleviated HFD-induced hepatic steatosis, prevented HFD-induced fat deposition and enhanced mitochondrial biogenesis genes in BAT and improved intestinal morphology and modulates SCFA availability.

Clinical Trial

分子量

308.41

Formula

C18H28O4
CAS 号

205687-03-2
性状

液体

颜色

Colorless to light yellow

结构分类
  • Phenols
  • Monophenols
初始来源
  • 植物
  • 茄科
  • 辣椒
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.18%

Data Sheet (525 KB) SDS (420 KB)

COA (257 KB) HNMR (200 KB) LCMS (158 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Baboota RK, et al. Dihydrocapsiate supplementation prevented high-fat diet-induced adiposity, hepatic steatosis, glucose intolerance, and gut morphological alterations in mice. Nutr Res. 2018;51:40-56.  [Content Brief]

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