Peimisine hydrochloride (Synonyms: Ebeiensine hydrochloride)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Peimisine hydrochloride  (Synonyms: Ebeiensine hydrochloride)

Peimisine (Ebeiensine) hydrochloride 是一种毒蕈碱 M 受体拮抗剂和血管紧张素转换酶 (ACE) 抑制剂。Peimisine hydrochloride 具有抗肿瘤、抗炎、抗高血压的活性。Peimisine hydrochloride 能诱导细胞凋亡，可用于咳嗽和哮喘研究。

Peimisine hydrochloride (Synonyms: Ebeiensine hydrochloride)

Peimisine hydrochloride Chemical Structure

CAS No. : 900498-44-4

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Peimisine hydrochloride 相关产品

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生物活性

Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research[1][2][3].

体外研究
(In Vitro)

Peimisine (17.43-92.07 μg/mL; 72 h) shows significant cytotoxic effects[3].
Peimisine (15 μg/mL; 24, 48 and 72 h) induces G0/G1 phase arrest and rising apoptosis rate[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Peimisine hydrochloride 相关抗体:

Apoptosis Analysis[2]

Cell Line: A2780 cells
Concentration: 15 μg/mL
Incubation Time: 24, 48 and 72 hours
Result: Induced G0/G1 phase arrest of A2780 cells in a time-dependent manner.

Cell Cytotoxicity Assay[2]

Cell Line: LLC, A2780, HepG2 and A549 cells
Concentration: 17.43-92.07 μg/mL
Incubation Time: 72 hours
Result: Inhibited LLC, A2780, HepG2 and A549 cells with the IC50 values of 20.75 μg/mL, 17.43 μg/mL, 92.07 μg/mL, 36.11 μg/mL, respectively.

分子量

464.08

Formula

C27H42ClNO3
CAS 号

900498-44-4
中文名称

贝母辛盐酸盐
结构分类
  • Alkaloids
  • Piperidine Alkaloids
初始来源
  • 植物
  • 百合科
  • 平贝母
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Pan F, et al. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis. Phytomedicine. 2014 Jul-Aug;21(8-9):1104-9.  [Content Brief]

    [2]. Armando Alberola-Die, et al. Peimine, an Anti-Inflammatory Compound from Chinese Herbal Extracts, Modulates Muscle-Type Nicotinic Receptors. Int J Mol Sci. 2021 Oct 19;22(20):11287.  [Content Brief]

    [3]. Dongdong Wang, et al. Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action. BMC Complement Altern Med. 2015 Feb 21;15:29.  [Content Brief]

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