1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

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1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone，一种喹诺酮类生物碱，是二酰基甘油酰基转移酶抑制剂和血管紧张素 II 受体阻断剂，IC50 值分别为 20.1 μM 和 34.1 μM。1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 显示出有效的抗幽门螺杆菌活性，MIC 值为 10 μg/mL。

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone Chemical Structure

CAS No. : 120693-53-0

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1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 相关产品

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生物活性

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL[1][2][3].

IC50 & Target

IC50: 20.1 μM (diacylglycerol acyltransferase)[3], 34.1 μM (angiotensin II receptor)[2]
体外研究
(In Vitro)

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows anti-Helicobacter pylori activity, with the MIC of 10 μg/mL, and has no effect on Helicobacter pylori urease activity at the concentration of 300 μg/mL[1].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-500 μM) shows a dose-dependent diacylglycerol acyltransferase (DGAT) inhibition, with an IC50 of 20.1 μM[3].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-20 μM) inhibits leukotriene biosynthesis in human polymorphonuclear granulocytes, with an IC50 of 10.1 μM[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 相关抗体:
分子量

337.50

Formula

C23H31NO
CAS 号

120693-53-0
结构分类
  • Alkaloids
  • Quinoline Alkaloids
初始来源
  • 植物
  • 芸香科
  • 吴茱萸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (527 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Rho TC, et, al. Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus. Biol Pharm Bull. 1999 Oct;22(10):1141-3.  [Content Brief]

    [2]. Lee HS, et, al. Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa. Phytotherapy Research. 1998 May; 12(3): 212-214.

    [3]. Ko JS, et, al. Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa. Planta Med. 2002 Dec;68(12):1131-3.  [Content Brief]

    [4]. Adams M, et, al. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004 Oct;70(10):904-8.  [Content Brief]

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