Epoetin beta (Synonyms: rhEPO; EPOCH; Genetical recombination)

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Epoetin beta  (Synonyms: rhEPO; EPOCH; Genetical recombination) 纯度: ≥95.0%

Epoetin beta (rhEPO) 是一种重组形式的促红细胞生成素。Epoetin beta 负责维持红细胞生成，可用于贫血的研究。

  • Epoetin beta (Synonyms: rhEPO; EPOCH; Genetical recombination)
  • Epoetin beta (Synonyms: rhEPO; EPOCH; Genetical recombination)

  1. Epoetin beta (Synonyms: rhEPO; EPOCH; Genetical recombination)
  2. Epoetin beta (Synonyms: rhEPO; EPOCH; Genetical recombination)

CAS No. : 122312-54-3

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2000 IU ￥9900 In-stock

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生物活性

Epoetin beta (rhEPO) is a recombinant form of erythropoietin. Epoetin beta is responsible for the maintenance of erythropoiesis and can be used for anaemia research[1].

种属

Human
体内研究
(In Vivo)

Epoetin beta (rhEPO) (1000 IU/kg; s.c.; three times per week over 14 days) prevents anaemia and enhances the radiosensitivity of solid growing DS-sarcomas[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, body weight 140-170 g[2]
Dosage: 1000 IU/kg
Administration: Subcutaneous injection, three times per week over 14 days starting 9 days before tumour implantation. Solid DS-sarcomas were induced by injecting DS-sarcoma cells (0.4 mL, approximately 104 cells/uL) subcutaneously into the hind food dorsum. A prolonged anaemia was induced in all animals by a single i.v. dose of carboplatin (45 mg/kg dissolved in isotonic saline at a concentration of 20 mg/mL) into the tail vein 3 days before tumour implantation.
Result: Prevented anaemia and significantly increased the radiosensitivity of solid growing DS-sarcomas, tumours showing pronounced hypoxia even under non-anaemic control conditions.

Clinical Trial

CAS 号

122312-54-3
性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Epoetin beta (Synonyms: rhEPO; EPOCH; Genetical recombination)
    EPO
纯度 & 产品资料

纯度: ≥95.0%

Data Sheet (513 KB) SDS (251 KB)

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)

参考文献

  • [1]. Cheer SM, et al. Epoetin Beta: a review of its clinical use in the treatment of anaemia in patients with cancer. Drugs. 2004;64(3):323-46.  [Content Brief]

    [2]. Thews O, et al. Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia. Br J Cancer. 1998 Sep;78(6):752-6.  [Content Brief]

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