Famciclovir-d4(Synonyms: BRL 42810-d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Famciclovir-d4 (Synonyms: BRL 42810-d4)

Famciclovir-d4 (BRL 42810-d4) 是 Famciclovir 的氘代物。Famciclovir(BRL 42810)是鸟嘌呤类似物，具有抗疱疹病毒活性。

Famciclovir-d4(Synonyms: BRL 42810-d4)

Famciclovir-d4 Chemical Structure

CAS No. : 1020719-42-9

规格 是否有货
2.5 mg Check price and availability
5 mg Check price and availability

* Please select Quantity before adding items.

生物活性

Famciclovir-d4 (BRL 42810-d4) is the deuterium labeled Famciclovir. Famciclovir (BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

325.36

Formula

C14H15D4N5O4
CAS 号

1020719-42-9
中文名称

泛昔洛韦 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Harrell AW, Wheeler SM, Pennick M, Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes. Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23.

    [3]. Perry CM, Wagstaff AJ. Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections. Drugs. 1995 Aug;50(2):396-415.

    [4]. Trépo C, Jezek P, Atkinson G, Famciclovir in chronic hepatitis B: results of a dose-finding study. J Hepatol. 2000 Jun;32(6):1011-8.

    [5]. Filer CW, Ramji JV, Allen GD, Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog. Xenobiotica. 1995 May;25(5):477-90.

    [6]. Wutzler P, Ulbricht A, Färber I. Antiviral efficacies of famciclovir, valaciclovir, and brivudin in disseminated herpes simplex virus type 1 infection in mice. Intervirology. 1997;40(1):15-21.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务