Rupatadine D4 fumarate(Synonyms: UR-12592 D4 fumarate)

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Rupatadine D4 fumarate (Synonyms: UR-12592 D4 fumarate)

Rupatadine D4 fumarate (UR-12592 D4 fumarate) 是Rupatadine fumarate 的氘代标记物。Rupatadine Fumarate (UR-12592 Fumarate) 富马酸盐是 PAF/H1 受体双抑制剂，Ki 值分别为0.55 μM 和 0.1 μM。

Rupatadine D4 fumarate(Synonyms: UR-12592 D4 fumarate)

Rupatadine D4 fumarate Chemical Structure

CAS No. : 1795153-63-7

规格 价格 是否有货
1 mg ￥2500 询问价格 & 货期
5 mg ￥5500 询问价格 & 货期

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生物活性

Rupatadine D4 fumarate (UR-12592 D4 fumarate) is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 μM(rabbit platelet membranes/guinea pig cerebellum membranes)[1][2][3].

分子量

536.05

Formula

C30H26D4ClN3O4
CAS 号

1795153-63-7
中文名称

富马酸卢帕他定 D4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21.

    [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60.

    [3]. Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.

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