Bosutinib D8(Synonyms: SKI-606 D8)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Bosutinib D8 (Synonyms: SKI-606 D8)

Bosutinib D8 (SKI-606 D8) 是 Bosutinib 的氘代物。Bosutinib 是 Src/Abl 的双抑制剂， IC50 分别为 1.2 nM 和 1 nM。

Bosutinib D8(Synonyms: SKI-606 D8)

Bosutinib D8 Chemical Structure

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生物活性

Bosutinib D8 (SKI-606 D8) is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively[1][2].

IC50 & Target

IC50: 1.2 nM (Src), 1 nM (Abl)[1]
分子量

538.50

Formula

C26H21D8Cl2N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977.

    [2]. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381.

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