Chloroquine-d5(Synonyms: 氯喹 d5)

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Chloroquine-d5 (Synonyms: 氯喹 d5)

Chloroquine D5 是 Chloroquine 的氘代物。Chloroquine 是一种广泛用于研究疟疾和类风湿性关节炎的抗疟疾和抗炎剂。Chloroquine 是 autophagy 和 toll-like receptors (TLRs) 的抑制剂。Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50=1.13 μM)。

Chloroquine-d5(Synonyms: 氯喹 d5)

Chloroquine-d5 Chemical Structure

CAS No. : 1854126-41-2

规格 价格 是否有货 数量
1 mg ￥2500 In-stock
5 mg ￥5500 In-stock
10 mg   询价  
50 mg   询价  

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生物活性

Chloroquine D5 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

IC50 & Target

HIV-1

 

Malaria

 

TLRs

 

SARS-COV-2

 

分子量

324.90

Formula

C18H21D5ClN3
CAS 号

1854126-41-2
中文名称

氯喹 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.

    [2]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.

    [3]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626.

    [4]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932.

    [5]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135.

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