Cromolyn-d5 sodium(Synonyms: Disodium Cromoglycate-d5; FPL-670-d5)

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Cromolyn-d5 sodium (Synonyms: Disodium Cromoglycate-d5; FPL-670-d5)

Cromolyn-d5 sodium (Disodium Cromoglycate-d5) 是 Cromolyn sodium 的氘代物。Cromolyn sodium (Disodium Cromoglycate; FPL-670) 是抗过敏化合物。Cromolyn sodium 是一种 GSK-3β 抑制剂，IC50 为 2.0 µM。

Cromolyn-d5 sodium(Synonyms: Disodium Cromoglycate-d5; FPL-670-d5)

Cromolyn-d5 sodium Chemical Structure

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生物活性

Cromolyn-d5 sodium (Disodium Cromoglycate-d5) is the deuterium labeled Cromolyn sodium. Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 µM.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

517.36

Formula

C23H9D5Na2O11
中文名称

色甘酸钠 d5 (钠盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Gan, X., et al., Treatment of mice with cromolyn sodium after reperfusion, but not prior to ischemia, attenuates small intestinal ischemia-reperfusion injury. Mol Med Rep, 2013. 8(3): p. 928-34.

    [3]. Ng, G. and A. Ohlsson, Cromolyn sodium for the prevention of chronic lung disease in preterm infants. Cochrane Database Syst Rev, 2012. 6: p. CD003059.

    [4]. Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618(17)30796-X.

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