Cetirizine D4

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Cetirizine D4 

Cetirizine D4 是Cetirizine 的氘代物。Cetirizine 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine 是一种特异的、口服有效的、H1 受体 的长效拮抗剂。Cetirizine 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。

Cetirizine D4

Cetirizine D4 Chemical Structure

CAS No. : 1219803-84-5

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生物活性

Cetirizine D4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

分子量

392.91

Formula

C21H21D4ClN2O3
CAS 号

1219803-84-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993.

    [2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.

    [3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

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