Clofibrate-d4(Synonyms: 氯贝特 d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Clofibrate-d4 (Synonyms: 氯贝特 d4)

Clofibrate-d4 是 Clofibrate 的氘代物。Clofibrate 是 PPAR 的激动剂，对人和鼠 PPARα 和 PPARγ 的 EC₅₀ 值分别为 55 μM，∼500 μM 和 50 μM，∼500 μM。

Clofibrate-d4 Chemical Structure

CAS No. : 1189654-03-2

规格		是否有货
1 mg		Check price and availability
5 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	Clofibrate-d4 is the deuterium labeled Clofibrate. Clofibrate is an agonist of PPAR, with EC₅₀s of 50 μM, ∼500 μM for murine PPARα and PPARγ, and 55 μM, ∼500 μM for human PPARα and PPARγ, respectively.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	246.72
Formula	C₁₂H₁₁D₄ClO₃
CAS 号	1189654-03-2
中文名称	氯贝特 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [3]. Chen Y, et al. Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells. J Pharm Pharm Sci. 2017;20(0):239-251. [4]. Chen SH, et al. Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood. PLoS One. 2017 Nov 2;12(11):e0187507.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务