L-Theanine-d5(Synonyms: L-Glutamic Acid γ-ethyl amide-d5; Nγ-Ethyl-L-glutamine-d5)

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L-Theanine-d5 (Synonyms: L-Glutamic Acid γ-ethyl amide-d5; Nγ-Ethyl-L-glutamine-d5)

L-Theanine-d5 (L-Glutamic Acid γ-ethyl amide-d5) 是 L-Theanine 的氘代物。L-Theanine (L-Glutamic Acid γ-ethyl amide）是一种存在绿茶叶片中的非蛋白氨基酸物质, 能阻断大脑中谷氨酸与谷氨酸受体结合，具有神经保护和抗氧化活性。 能通过口服 L-Theanine (L-Glutamic Acid γ-ethyl amide） 抑制皮层神经元兴奋从而产生抗应激作用 。

L-Theanine-d5(Synonyms: L-Glutamic Acid γ-ethyl amide-d5; Nγ-Ethyl-L-glutamine-d5)

L-Theanine-d5 Chemical Structure

CAS No. : 1217451-85-8

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生物活性

L-Theanine-d5 (L-Glutamic Acid γ-ethyl amide-d5) is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

179.23

Formula

C7H9D5N2O3
CAS 号

1217451-85-8
中文名称

L-茶氨酸 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Vuong QV, et al. L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 2011 Aug 30;91(11):1931-9.

    [3]. Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45.

    [4]. Takeshima M, et al. l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes. J Clin Biochem Nutr. 2016 Sep;59(2):93-99.

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