6-Aminocaproic acid-d10(Synonyms: EACA-d10; Epsilon-Amino-n-caproic Acid-d10; 6-Aminohexanoic acid-d10)

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6-Aminocaproic acid-d10 (Synonyms: EACA-d10; Epsilon-Amino-n-caproic Acid-d10; 6-Aminohexanoic acid-d10)

6-Aminocaproic acid-d10 (EACA-d10) 是 6-Aminocaproic acid 的氘代物。6-Aminocaproic acid (EACA)，一种单氨基羧酸，是有效和具有口服活性的纤溶酶和纤溶酶原的抑制剂。6-Aminocaproic acid 是一种有效的抗纤维蛋白溶解剂。6-Aminocaproic acid 通过竞争性结合纤溶酶原上的赖氨酸残基来防止血块溶解，抑制纤溶酶的形成并减少纤维蛋白溶解。6-Aminocaproic acid 可用于研究出血性疾病。

6-Aminocaproic acid-d10(Synonyms: EACA-d10; Epsilon-Amino-n-caproic Acid-d10; 6-Aminohexanoic acid-d10)

6-Aminocaproic acid-d10 Chemical Structure

CAS No. : 461432-51-9

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生物活性

6-Aminocaproic acid-d10 (EACA-d10) is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

141.23

Formula

C6H3D10NO2
CAS 号

461432-51-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Griffin JD, et, al. Epsilon-aminocaproic acid (EACA). Semin Thromb Hemost. Summer 1978;5(1):27-40.

    [3]. Kaye S, et, al. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS). J Zoo Wildl Med. 2016 Jun;47(2):397-404.

    [4]. Brown JC, et, al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am J Vet Res. 2016 Nov;77(11):1258-1265.

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