Minoxidil sulfate-d10

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Minoxidil sulfate-d10 

Minoxidil sulfate-d10 是 Minoxidil sulfate 的氘代物。Minoxidil sulfate 是一种有效的 ATP 敏感的 K+ 通道 (K+ channel) 激动剂，是米诺地尔的硫酸代谢物。Minoxidil sulfate 被认为是一种血管扩张试剂，在动物实验模型中，促进头发生长。

Minoxidil sulfate-d10

Minoxidil sulfate-d10 Chemical Structure

CAS No. : 1260373-92-9

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生物活性

Minoxidil sulfate-d10 is the deuterium labeled Minoxidil sulfate. Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo[1][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

299.37

Formula

C9H5D10N5O4S
CAS 号

1260373-92-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. A E Buhl, et al. Minoxidil sulfate is the active metabolite that stimulates hair follicles. J Invest Dermatol. 1990 Nov;95(5):553-7.

    [3]. Yan-ting Gu, et al. Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway.Neuropharmacology 2013 Dec;75:407-15.doi: 10.1016/j.neuropharm.

    [4]. Y Nakaya, et al.Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells. J Dermatol Sci. 1994 Jul;7 Suppl:S104-8.

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