Benzquinamide-d3 hydrochloride

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Benzquinamide-d3 hydrochloride 

Benzquinamide-d3 hydrochloride 是 Benzquinamide hydrochloride 的氘代物。Benzquinamide (P2647) hydrochloride 是一种止吐剂, 并可以与 α2A, α2B, 以及α2C 肾上腺素能受体（α2-AR）结合，Ki值分别为 1,365, 691 和 545 nM。

Benzquinamide-d3 hydrochloride

Benzquinamide-d3 hydrochloride Chemical Structure

CAS No. : 1329633-94-4

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生物活性

Benzquinamide-d3 hydrochloride is the deuterium labeled Benzquinamide hydrochloride. Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

443.98

Formula

C22H30D3ClN2O5
CAS 号

1329633-94-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Elisabet Gregori-Puigjané, et al. Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11178-11183. doi: 10.1073/pnas.1204524109

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