Diltiazem-(acetoxy-d3) (hydrochloride)(Synonyms: 盐酸地尔硫卓 d3) (盐酸盐))

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Diltiazem-(acetoxy-d3) (hydrochloride) (Synonyms: 盐酸地尔硫卓 d3) (盐酸盐))

Diltiazem-(acetoxy-d3) hydrochloride 是 Diltiazem hydrochloride 的氘代物。Diltiazem hydrochloride是钙离子流入抑制剂(缓慢通道阻断剂或钙拮抗剂)。

Diltiazem-(acetoxy-d3) (hydrochloride)(Synonyms: 盐酸地尔硫卓 d3) (盐酸盐))

Diltiazem-(acetoxy-d3) (hydrochloride) Chemical Structure

CAS No. : 1217860-13-3

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生物活性

Diltiazem-(acetoxy-d3) hydrochloride is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

454.00

Formula

C22H24D3ClN2O4S

CAS 号

1217860-13-3

中文名称

盐酸地尔硫卓 d3) (盐酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12.

    [3]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63.

    [4]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40.

    [5]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40.

    [6]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author’s transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.

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