Butamben-d9(Synonyms: Butyl 4-aminobenzoate-d9)

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Butamben-d9 (Synonyms: Butyl 4-aminobenzoate-d9)

Butamben-d9 (Butyl 4-aminobenzoate-d9) 是 Butamben 的氘代物。Butamben (Butyl 4-aminobenzoate) 可长期缓解疼痛，而不会损害运动功能或其他感觉功能。

Butamben-d9(Synonyms: Butyl 4-aminobenzoate-d9)

Butamben-d9 Chemical Structure

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生物活性

Butamben-d9 (Butyl 4-aminobenzoate-d9) is the deuterium labeled Butamben. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

202.30

Formula

C11H6D9NO2
中文名称

对氨基苯甲酸丁酯 d9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Cereda CM, et al. Liposomal butamben gel formulations: toxicity assays and topical anesthesia in an animal model. J Liposome Res. 2017 Mar;27(1):74-82.

    [3]. Rampaart LJA, et, al. The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells. Anesth Analg. 2008 Jun;106(6):1778-83.

    [4]. Berg RJV, et, al. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. Anesthesiology. 1995 Jun;82(6):1463-73.

    [5]. Kolesnikov YA, et, al. Analgesic synergy between topical morphine and butamben in mice. Anesth Analg. 2003 Oct;97(4):1103-7, table of contents.

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