Bisoprolol-d7 hemifumarate(Synonyms: 富马酸比索洛尔 d7 (hemifumarate))

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Bisoprolol-d7 hemifumarate (Synonyms: 富马酸比索洛尔 d7 (hemifumarate))

Bisoprolol-d7 hemifumarate 是 Bisoprolol hemifumarate 的氘代物。Bisoprolol hemifumarate 是 β1 肾上腺素受体 (β1 adrenergic receptor) 阻断剂。

Bisoprolol-d7 hemifumarate(Synonyms: 富马酸比索洛尔 d7 (hemifumarate))

Bisoprolol-d7 hemifumarate Chemical Structure

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生物活性

Bisoprolol-d7 hemifumarate is the deuterium labeled Bisoprolol hemifumarate. Bisoprolol hemifumarate is a selective type β1 adrenergic receptor blocker.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

448.56

Formula

C22H28D7NO8
中文名称

富马酸比索洛尔 d7 (hemifumarate)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Matsui, S., et al., Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits. Herz, 2000. 25(3): p. 267-70.

    [3]. Wargon, M., et al., Acute effects of bisoprolol on respiratory sinus arrhythmia. Fundam Clin Pharmacol, 1998. 12(4): p. 451-6.

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