Ambroxol-d5 hydrochloride(Synonyms: NA-872-d5 hydrochloride)

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Ambroxol-d5 hydrochloride (Synonyms: NA-872-d5 hydrochloride)

Ambroxol-d5 (NA-872-d5) hydrochloride 是 Ambroxol hydrochloride 的氘代物。Ambroxol hydrochloride (NA-872 hydrochloride) 是前药溴己辛的活性代谢产物，具有强效祛痰作用。Ambroxol hydrochloride 是一种葡糖脑苷脂酶 (GCase) 伴侣，可增加葡糖脑苷脂酶的活性。Ambroxol hydrochloride 可诱导肺自噬，并有用于帕金森氏病和神经性戈谢病研究的潜力。

Ambroxol-d5 hydrochloride(Synonyms: NA-872-d5 hydrochloride)

Ambroxol-d5 hydrochloride Chemical Structure

CAS No. : 2741380-71-0

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生物活性

Ambroxol-d5 (NA-872-d5) hydrochloride is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

419.59

Formula

C13H14D5Br2ClN2O
CAS 号

2741380-71-0
中文名称

盐酸氨溴索 d5 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218.

    [3]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775.

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