7-Ketolithocholic acid-d5(Synonyms: 3α-Hydroxy-7-oxo-5β-cholanic acid-d5)

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7-Ketolithocholic acid-d5 (Synonyms: 3α-Hydroxy-7-oxo-5β-cholanic acid-d5)

7-Ketolithocholic acid-d5 (3α-Hydroxy-7-oxo-5β-cholanic acid-d5) 是 7-Ketolithocholic acid 的氘代物。7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) 是一种胆汁酸，可以被吸收，抑制内源性胆汁酸的产生和胆汁胆固醇的分泌。

7-Ketolithocholic acid-d5(Synonyms: 3α-Hydroxy-7-oxo-5β-cholanic acid-d5)

7-Ketolithocholic acid-d5 Chemical Structure

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生物活性

7-Ketolithocholic acid-d5 (3α-Hydroxy-7-oxo-5β-cholanic acid-d5) is the deuterium labeled 7-Ketolithocholic acid. 7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

395.59

Formula

C24H33D5O4
中文名称

3α-羟基-7-氧代-5β-胆烷酸 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Choucair I, et al. Quantification of bile acids: a mass spectrometry platform for studying gut microbe connectionto metabolic diseases. J Lipid Res. 2020 Feb;61(2):159-177.

    [3]. Salen G, et al. Effect of 7-ketolithocholic acid on bile acid metabolism in humans. Gastroenterology. 1982 Aug;83(2):341-7.

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