Deudextromethorphan hydrobromide hydrate(Synonyms: AVP-786 hydrobromide hydrate)

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Deudextromethorphan hydrobromide hydrate (Synonyms: AVP-786 hydrobromide hydrate)

Deudextromethorphan (AVP-786) hydrobromide hydrate 是右美沙芬/奎尼丁 (AVP-923, Nuedexta) 的氘化形式。Deudextromethorphan hydrobromide hydrate是一种谷氨酸靶向剂，是一种具有口服活性的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。Deudextromethorphan hydrobromide hydrate 可用于假性延髓效应、创伤性脑损伤、行为去抑制和阿尔兹海默症中激越的研究[1][2][3].

Deudextromethorphan hydrobromide hydrate(Synonyms: AVP-786 hydrobromide hydrate)

Deudextromethorphan hydrobromide hydrate Chemical Structure

CAS No. : 1373497-18-7

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生物活性

Deudextromethorphan (AVP-786) hydrobromide hydrate is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan hydrobromide hydrate, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan hydrobromide hydrate can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].

分子量

376.36

Formula

C18H22D6BrNO2
CAS 号

1373497-18-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Khoury R, et al. AVP-786 as a promising treatment option for Alzheimer’s Disease including agitation. Expert Opin Pharmacother. 2021 May;22(7):783-795.

    [2]. Garay RP, et al. AVP-786 for the treatment of agitation in dementia of the Alzheimer’s type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132.

    [3]. Hecking J, et al. Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders. Chronic Stress (Thousand Oaks). 2021 Jun 2;5:24705470211020446.

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