(R)-Bicalutamide-d4(Synonyms: (R)-比卡鲁胺 d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
(R)-Bicalutamide-d4 (Synonyms: (R)-比卡鲁胺 d4)

(R)-Bicalutamide-d4 是 (R)-Bicalutamide 的氘代物。(R)-Bicalutamide 是 Bicalutamide (HY-14249) 的 R 型对映体。(R)-Bicalutamide 是一种雄激素受体 (AR) 拮抗剂，具有抗肿瘤活性。(R)-Bicalutamide 广泛用于前列腺癌的研究。

(R)-Bicalutamide-d4(Synonyms: (R)-比卡鲁胺 d4)

(R)-Bicalutamide-d4 Chemical Structure

CAS No. : 1217826-87-3

规格 是否有货
1 mg Check price and availability

* Please select Quantity before adding items.

生物活性

(R)-Bicalutamide-d4 is the deuterium labeled (R)-Bicalutamide. (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide (HY-14249). (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

434.40

Formula

C18H10D4F4N2O4S
CAS 号

1217826-87-3
中文名称

(R)-比卡鲁胺 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Hongli Liu, et al. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation. J Comput Aided Mol Des. 2016 Dec;30(12):1189-1200.

    [3]. Sara Pignatta, et al. Prolonged exposure to (R)-bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome. Mol Cell Endocrinol. 2014 Jan 25;382(1):314-324.

    [4]. Anna Tesei, et al. Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models. PLoS One. 2013; 8(5): e62657.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务