3-O-Methyldopa-d3 hydrate(Synonyms: 3-Methoxy-L-tyrosine-d3 hydrate; 3-O-Methyl-L-DOPA-d3 hydrate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
3-O-Methyldopa-d3 hydrate (Synonyms: 3-Methoxy-L-tyrosine-d3 hydrate; 3-O-Methyl-L-DOPA-d3 hydrate)

3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) hydrate 是 3-O-Methyldopa 的氘代物。3-O-Methyldopa (3-Methoxy-L-tyrosine) 是一种由邻苯二酚-O-甲基转移酶 (COMT) 形成的 L-DOPA 代谢物。3-O-Methyldopa 竞争性抑制 L-DOPA和多巴胺 (dopamine) 的药效学。

3-O-Methyldopa-d3 hydrate(Synonyms: 3-Methoxy-L-tyrosine-d3 hydrate; 3-O-Methyl-L-DOPA-d3 hydrate)

3-O-Methyldopa-d3 hydrate Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) hydrate is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

232.25

Formula

C10H12D3NO5
中文名称

3-O-甲基多巴 D3 (水合物)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务