Volinanserin-d4 hydrochloride(Synonyms: 氟利色林 d4 (盐酸盐))

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Volinanserin-d4 hydrochloride (Synonyms: 氟利色林 d4 (盐酸盐))

Volinanserin-d4 (MDL100907-d4) hydrochloride 是 Volinanserin hydrochlorid 的氘代物。Volinanserin hydrochlorid 是一种有效的，选择性的 5-HT2 受体拮抗剂，Ki 值为 0.36 nM，对其选择性是对 5-HT1c，alpha-1 和 DA D2 受体的 300 倍，可用于精神疾病的研究。

Volinanserin-d4 hydrochloride(Synonyms: 氟利色林 d4 (盐酸盐))

Volinanserin-d4 hydrochloride Chemical Structure

CAS No. : 1217617-73-6

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生物活性

Volinanserin-d4 (MDL100907-d4) hydrochloride is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

413.95

Formula

C22H25D4ClFNO3
CAS 号

1217617-73-6
中文名称

氟利色林 d4 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91.

    [3]. Ardayfio PA, et al. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. J Pharmacol Exp Ther. 2008 Dec;327(3):891-7.

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