Calcifediol-d6 monohydrate(Synonyms: 25-hydroxy Vitamin D3-d6 monohydrate)

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Calcifediol-d6 monohydrate (Synonyms: 25-hydroxy Vitamin D3-d6 monohydrate)

Calcifediol-d6 (25-hydroxy Vitamin D3-d6) monohydrate 是 Calcifediol monohydrate 的氘代物。Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate) 是由维生素 D3 在肝中经羟基化后得到的前激素，是有效的 VDR 抑制剂。

Calcifediol-d6 monohydrate(Synonyms: 25-hydroxy Vitamin D3-d6 monohydrate)

Calcifediol-d6 monohydrate Chemical Structure

CAS No. : 2483831-70-3

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生物活性

Calcifediol-d6 (25-hydroxy Vitamin D3-d6) monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), a major circulating metabolite of vitamin D3, is a potent VDR inhibitor[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

424.69

Formula

C27H40D6O3
CAS 号

2483831-70-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.

    [3]. Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38(6):BSR20180595.

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