DPPC-d9(Synonyms: 129Y83-d9)

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DPPC-d9 (Synonyms: 129Y83-d9)

DPPC-d9 (129Y83-d9) 是 DPPC 的氘代物。DPPC (129Y83) 是一种磷酸甘油酯，可用于制备脂质体单层。DPPC-脂质体可有效地用作小鼠中诱导针对 GSL 抗原的免疫应答的递送载体。

DPPC-d9(Synonyms: 129Y83-d9)

DPPC-d9 Chemical Structure

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生物活性

DPPC-d9 (129Y83-d9) is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

743.09

Formula

C40H71D9NO8P
中文名称

二棕榈酰磷脂酰胆碱 d9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

    [3]. Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201.

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