O-Desmethyl Tramadol-d6

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O-Desmethyl Tramadol-d6 

O-Desmethyl Tramadol-d6 是 O-Desmethyl Tramadol 的氘代物。O-Desmethyl Tramadol 是 Tramadol 的主要活性代谢物。O-Desmethyl Tramadol 主要负责其 µ-阿片受体相关的镇痛作用。Tramadol 主要通过细胞色素 P450 (CYP) 2D6 酶代谢为O-Demethyltramadol。

O-Desmethyl Tramadol-d6

O-Desmethyl Tramadol-d6 Chemical Structure

CAS No. : 873928-73-5

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生物活性

O-Desmethyl Tramadol-d6 is the deuterium labeled O-Desmethyl Tramadol. O-Desmethyl Tramadol is a primary active metabolite of Tramadol. O-Desmethyl Tramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme[1].

分子量

255.39

Formula

C15H17D6NO2

CAS 号

873928-73-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lee J, et al. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Des Devel Ther. 2019;13:1751-1761.

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