Aliskiren D6 hemifumarate(Synonyms: CGP 60536 D6 hemifumarate; CGP60536B D6 hemifumarate; SPP 100 D6 hemifumarate)

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Aliskiren D6 hemifumarate (Synonyms: CGP 60536 D6 hemifumarate; CGP60536B D6 hemifumarate; SPP 100 D6 hemifumarate)

Aliskiren D6 hemifumarate (CGP 60536 D6 hemifumarate) 是 Aliskiren hemifumarate 的氘代物。Aliskiren hemifumarate 是一种直接的口服活性的肾素 (renin) 抑制剂，IC50 为 1.5 nM。

Aliskiren D6 hemifumarate(Synonyms: CGP 60536 D6 hemifumarate; CGP60536B D6 hemifumarate; SPP 100 D6 hemifumarate)

Aliskiren D6 hemifumarate Chemical Structure

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生物活性

Aliskiren D6 hemifumarate (CGP 60536 D6 hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].

IC50 & Target

IC50: 1.5 nM (renin)[1]
分子量

615.83

Formula

C34H51D6N3O10
中文名称

阿利克仑半富马酸盐 D6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754-758.

    [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31.

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