Methocarbamol-13C,d3

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Methocarbamol-13C,d3 

Methocarbamol-13C,d3 是一种 13C- 和氘代标记的 Methocarbamol。Methocarbamol 是一种具有口服活性中枢肌肉松弛剂，可阻断 Nav1.4 肌肉通道。Methocarbamol 可逆地影响电压依赖性的 Nav1.4 通道失活。Methocarbamol 具有用于肌肉痉挛和疼痛综合症研究的潜力。

Methocarbamol-13C,d3

Methocarbamol-13C,d3 Chemical Structure

CAS No. : 2747917-88-8

规格 是否有货
1 mg 询价
5 mg 询价

* Please select Quantity before adding items.

生物活性

Methocarbamol-13C,d3 is the 13C- and deuterium labeled Methocarbamol. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[79].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

245.25

Formula

C1013CH12D3NO5
CAS 号

2747917-88-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

    [2]. Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60(1): p. 104-6.

    [3]. Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39(2): p. 193-4.

    [4]. Yaxin Zhang, et al. Methocarbamol blocks muscular Na v 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2020 Oct 11.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务