标签归档：三粒

Tricetin (Synonyms: 三粒小麦黄酮)

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Tricetin  (Synonyms: 三粒小麦黄酮) 纯度: 99.19%

Tricetin 是一种有效的竞争性 Keap1-Nrf2 蛋白相互作用 (PPI) 抑制剂。Tricetin 作用于帕金森病模型，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡 (apoptosis) 通路来保护 6-OHDA 诱导的神经毒性。

Tricetin (Synonyms: 三粒小麦黄酮)

Tricetin Chemical Structure

CAS No. : 520-31-0

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1 mg ￥1200 In-stock
5 mg ￥3400 In-stock
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Tricetin 相关产品

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生物活性

Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson’s disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway[1].

体外研究
(In Vitro)

Tricetin is mainly found in natural plants such as Ginkgo biloba L., Carica papaya L. and Murraya exotica L. Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of C. elegans. Tricetin has cytostatic properties and anti-metastatic activity of various solid tumors[1].
Pretreatment with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200 μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis[1].
Tricetin (80 μM; for 1, 2 and 4 h) markedly decreased the expressions of p-JNK and p-p38[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Tricetin 相关抗体:

Cell Viability Assay

Cell Line: SH-SY5Y cells
Concentration: 20, 40, and 80 μM
Incubation Time: Pretreatment for 4 h followed by 6-OHDA (200 μM) for 24 h
Result: Significantly increased 6-OHDA-induced SH-SY5Y cells viability.

Western Blot Analysis

Cell Line: SH-SY5Y cells
Concentration: 80 μM
Incubation Time: 1, 2 and 4 h
Result: Markedly decreased the expressions of p-JNK and p-p38. 

分子量

302.24

Formula

C15H10O7
CAS 号

520-31-0
性状

固体

颜色

Light yellow to brown

中文名称

三粒小麦黄酮
结构分类
  • Flavonoids
  • Flavonols
初始来源
  • 植物
  • 柏科
  • 北美香柏
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.19%

Data Sheet (531 KB) SDS (393 KB)

COA (193 KB) LCMS (94 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Ren J, et al. Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson’s disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. Toxicol Appl Pharmacol. 2019;378:114617.  [Content Brief]

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