标签归档：东革

Eurycomalactone (Synonyms: 东革内酯)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Eurycomalactone  (Synonyms: 东革内酯) 纯度: 98.99%

Eurycomalactone 是一种可以从 Eurycoma longifolia Jack 中分离得到的活性拟松类化合物。Eurycomalactone 是一种有效的NF-κB 抑制剂，其 IC50 值为 0.5 μM。Eurycomalactone 可抑制蛋白合成，降低 cyclin D1 蛋白水平。Eurycomalactone 通过阻滞细胞周期于G2/M 期和延迟 DNA 双链断裂修复来提高放射敏感性。Eurycomalactone 抑制 AKT/NF-κB 信号通路的激活，诱导细胞凋亡并增强对 Cisplatin (HY-17394) 的化疗敏感性。

Eurycomalactone (Synonyms: 东革内酯)

Eurycomalactone Chemical Structure

CAS No. : 23062-24-0

规格 价格 是否有货 数量
1 mg ￥1800 In-stock
5 mg ￥4300 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Eurycomalactone 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Kinase Inhibitor Library
  • NF-κB Signaling Compound Library
  • PI3K/Akt/mTOR Compound Library
  • Stem Cell Signaling Compound Library
  • Natural Product Library
  • Autophagy Compound Library
  • Anti-Aging Compound Library
  • Covalent Screening Library
  • Antioxidant Compound Library
  • Differentiation Inducing Compound Library
  • Oxygen Sensing Compound Library
  • Terpenoids Library
  • Glycolysis Compound Library
  • Pyroptosis Compound Library
  • Cytoskeleton Compound Library
  • Glutamine Metabolism Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Lung Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Cancer Metabolism Compound Library
  • Anti-Obesity Compound Library
  • Angiogenesis-Related Compound Library
  • Mitochondria-Targeted Compound Library
  • Transcription Factor-Targeted Library
  • Glucose Metabolism Compound Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library
  • Antidepressant Compound Library
  • Plant-Sourced Natural Product Library
  • Anti-Prostate Cancer Compound Library
  • Anti-Pulmonary Fibrosis Compound Library
  • Cancer Stem Cells Compound Library
  • Heterocyclic Compound Library
  • Pain-Related Compound Library
  • Membrane Protein-targeted Compound Library
  • Cysteine Targeted Covalent Library
  • Cell Death Library
  • Serine/Threonine Kinase Inhibitor Library
  • Anti-Hematopathy Compound Library
  • Anti-Ovarian Cancer Compound Library
  • Multi-Target Compound Library
  • Radioprotector Library

•同靶点产品:

•同靶点蛋白产品:

生物活性

Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3].

IC50 & Target

IC50: 0.5 μM (NF-κB)[1]
体外研究
(In Vitro)

Eurycomalactone (24, 48 and 72 h) selectively inhibits the viability of A549 and COR-L23 cells Eurycomalactone inhibits the viability of A549 cells with IC50 values of 20.17, 3.77, and 1.90 μM for 24, 48 and 72 hours, respectively. Eurycomalactone inhibits the viability of COR-L23 cells with IC50 values of 25.02, 2.74, and 1.80 μM for 24, 48 and 72 hours, respectively[1].
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) promotes Non-small cell lung cancer (NSCLC) cells apoptosis[2].
Eurycomalactone (0-25.05 μM; 24 h; A549 and COR-L23 cells) induces cell cycle arrest at the radiosensitive G2/M phase and induces apoptosis in irradiated Non-small cell lung cancer (NSCLC) cells. Eurycomalactone downregulated the key G2/M regulatory proteins in irradiated Non-small cell lung cancer (NSCLC) cells[1].
Eurycomalactone (2.5-25 μM; 24 h; A549 cells) suppressed the repair of radiation-Induced DNA double-strand breaks[1].
Eurycomalactone (2.29-156.3 μM; 24 h; A549 and Calu-1 cells) suppresses AKT/NF-κB activation in Non-small cell lung cancer (NSCLC) cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Eurycomalactone 相关抗体:

Apoptosis Analysis[2]

Cell Line: A549 and Calu-1 cells
Concentration: 2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time: 24 hours
Result: Increased the apoptotic rates in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: A549 and COR-L23 cells
Concentration: 1.57, 2.57, 20.17 and 25.05 μM
Incubation Time: 24 hours
Result: Induced cell cycle arrest at G2/M phase in irradiated cells and increased the sub-G1 population. A549 and COR-L23 cells

Western Blot Analysis[2]

Cell Line: A549 and Calu-1 cells
Concentration: 2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time: 24 hours
Result: Induced the expression levels of active caspase-3 and active PARP (cleaved form), while decreased Bcl-xL and surviving.

Western Blot Analysis[1]

Cell Line: A549 and COR-L23 cells
Concentration: 1.57, 2.57, 20.17 and 25.05 μM
Incubation Time: 24 hours
Result: Downregulated the expression of both G2/M regulatory proteins in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: A549 and COR-L23 cells
Concentration: 2.29, 10.14, 12.02, 20.81, 80.77, and 156.3 μM
Incubation Time: 24 hours
Result: inhibited the expression levels of p(S473)-AKT, total AKT, p(S536)-NF-κB p65 and total NF-κB p65.

分子量

348.39

Formula

C19H24O6
CAS 号

23062-24-0
性状

固体

颜色

White to off-white

中文名称

东革内酯
结构分类
  • Terpenoids
  • Diterpenoids
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (287.03 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8703 mL 14.3517 mL 28.7035 mL
5 mM 0.5741 mL 2.8703 mL 5.7407 mL
10 mM 0.2870 mL 1.4352 mL 2.8703 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

扫码获得
动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.99%

Data Sheet (623 KB) SDS (251 KB)

COA (185 KB) HNMR (159 KB) CNMR (164 KB) RP-HPLC (339 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175.  [Content Brief]

    [2]. Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454.  [Content Brief]

    [3]. Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务