标签归档：乳糖

Lacto-N-tetraose (Synonyms: 乳糖-N-四糖)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Lacto-N-tetraose  (Synonyms: 乳糖-N-四糖)

Lacto-N-tetraose 是天然存在于人乳中的人乳低聚糖 (HMOs) 的重要核心结构。Lacto-N-tetraose 是由半乳糖、N-乙酰氨基葡萄糖和葡萄糖组成。Lacto-N-tetraose 具有益生元作用、免疫调节作用、抗炎作用、肠道细胞反应调节作用、抗菌活性和抗病毒活性。Lacto-N-tetraose 已被广泛添加到婴儿配方奶粉中。

Lacto-N-tetraose (Synonyms: 乳糖-N-四糖)

Lacto-N-tetraose Chemical Structure

CAS No. : 14116-68-8

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Lacto-N-tetraose 相关产品

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生物活性

Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula[1].

体外研究
(In Vitro)

HMOs exhibits antimicrobial and antibiofilm activity against Streptococcus agalactiae, antibiofilm activity against Methicillin-resistant Staphylococcus aureus (MRSA), and antimicrobial activity against both Acinetobacter baumannii and Clostridium difficile[2].
Lacto-N-tetraose (500-2000 μg/mL) does not cause clastogenic or aneugenic signs in human peripheral blood lymphocytes, nor increase the percentage of micronucleated cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Lacto-N-tetraose 相关抗体:
体内研究
(In Vivo)

Lacto-N-tetraose (1000-4000 mg/kg; p.o.; daily for 90 days) does not show toxicity in neonatal SD rats[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female neonatal SD rats (housed together with dam until weaning after 21 days)[3]
Dosage: 1000, 25000 and 4000 mg/kg 
Administration: p.o.; daily for 90 days
Result: Did not show toxicity on clinical observations, body weight, food consumption, development and maturation, clinical pathology, organ weights or histopathology.

分子量

707.63

Formula

C26H45NO21
CAS 号

14116-68-8
中文名称

乳糖-N-四糖
结构分类
  • Saccharides
  • Polysaccharides
  • Others
初始来源
  • 内源性代谢物
  • 人肠道微生物代谢物

human
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (542 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Zhu Y, et al. Physiological effects, biosynthesis, and derivatization of key human milk tetrasaccharides, lacto-N-tetraose, and lacto-N-neotetraose. Crit Rev Biotechnol. 2022 Jun;42(4):578-596.  [Content Brief]

    [2]. Craft KM, Thomas HC, Townsend SD. Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus. Org Biomol Chem. 2019 Feb 13;17(7):1893-1900.  [Content Brief]

    [3]. Phipps KR, et al. Preclinical safety evaluation of the human-identical milk oligosaccharide lacto-N-tetraose. Regul Toxicol Pharmacol. 2018 Nov;99:260-273.  [Content Brief]

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