Tamsulosin hydrochloride (Synonyms: 盐酸坦索罗辛; (R)-(-)-YM12617; LY253351)

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Tamsulosin hydrochloride  (Synonyms: 盐酸坦索罗辛; (R)-(-)-YM12617; LY253351) 纯度: 99.81%

Tamsulosin hydrochloride ( (R)-(-)-YM12617) 是一种 α1 肾上腺素能受体 (α1-adrenergic receptor) 抑制剂。Tamsulosin hydrochloride 常用于前列腺增生的研究。在动物模型中,Tamsulosin hydrochloride 可减缓腹主动脉瘤的生长。

Tamsulosin hydrochloride                                          (Synonyms: 盐酸坦索罗辛; (R)-(-)-YM12617;  LY253351)

Tamsulosin hydrochloride Chemical Structure

CAS No. : 106463-17-6

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生物活性

Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models[1].

IC50 & Target[1]

α1-adrenergic receptor

 

Clinical Trial

分子量

444.97

Formula

C20H29ClN2O5S

CAS 号

106463-17-6

性状

固体

颜色

White to off-white

中文名称

盐酸坦索罗辛;盐酸坦洛新;盐酸坦索洛新

结构分类
  • Alkaloids
  • Other Alkaloids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 62.5 mg/mL (140.46 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2473 mL 11.2367 mL 22.4734 mL
5 mM 0.4495 mL 2.2473 mL 4.4947 mL
10 mM 0.2247 mL 1.1237 mL 2.2473 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.81%

Data Sheet (597 KB) SDS (252 KB)

COA (193 KB) HNMR (283 KB) LCMS (84 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Christopher Chapple, et al. Tamsulosin: an overview. World J Urol. 2002 Apr;19(6):397-404.  [Content Brief]

    [2]. William G. Montgomery, BA, et al. Tamsulosin Attenuates Abdominal Aortic Aneurysm Growth. Surgery. 2018 Nov; 164(5): 1087-1092.  [Content Brief]

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