标签归档：奎尼宁

Quinidine sulfate dihydrate (Synonyms: 硫酸奎尼宁)

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Quinidine sulfate dihydrate  (Synonyms: 硫酸奎尼宁)

Quinidine sulfate dihydrate 是一种抗心律失常剂。Quinidine sulfate dihydrate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+ 通道 (K+ channel) 的有效阻断剂，其 IC50 值为 19.9 μM，也可诱导凋亡。Quinidine sulfate dihydrate 也可用作疟疾的研究。

Quinidine sulfate dihydrate (Synonyms: 硫酸奎尼宁)

Quinidine sulfate dihydrate Chemical Structure

CAS No. : 6591-63-5

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生物活性

Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research[1][2][3][4].

IC50 & Target

IC50: cytochrome P450db; amphetamine metabolism[1]
体外研究
(In Vitro)

Quinidine sulfate dihydrate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Quinidine sulfate dihydrate 相关抗体:
体内研究
(In Vivo)

Quinidine sulfate dihydrate shows effects on the PTZ-induced seizure threshold[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).

分子量

405.50

Formula

C21H30N2O7S
CAS 号

6591-63-5
中文名称

硫酸奎尼宁
结构分类
  • Alkaloids
  • Quinoline Alkaloids
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (542 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13.  [Content Brief]

    [2]. Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.  [Content Brief]

    [3]. Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7.  [Content Brief]

    [4]. Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31.  [Content Brief]

    [5]. Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988.  [Content Brief]

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