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Anisodamine (Synonyms: 山莨菪碱; 6-Hydroxyhyoscyamine) 纯度: 98.01%
Anisodamine (6-Hydroxyhyoscyamine),颠茄生物碱,也是一种非亚型的选择性毒蕈碱和烟碱类胆碱受体拮抗剂。Anisodamine 用于中医研究多种疾病,主要用于改善休克状态下的微循环,也可用于有机磷中毒。
Anisodamine Chemical Structure
CAS No. : 55869-99-3
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥4180 | 询价 | |
1 mg | ¥1300 | In-stock | |
5 mg | ¥3800 | 询价 | |
10 mg | 询价 | ||
50 mg | 询价 |
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生物活性 |
Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning[1][2]. |
IC50 & Target |
Nicotinic cholinoceptor[1] |
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体外研究 (In Vitro) |
Anisodamine (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuates average fluorescence intensity of α-bungarotoxin binding compared with Ach alone[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Anisodamine (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
305.37 |
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Formula |
C17H23NO4 |
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CAS 号 |
55869-99-3 |
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性状 |
固体 |
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颜色 |
White to off-white |
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中文名称 |
山莨菪碱;阿托品杂质 E |
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结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO 中的溶解度 : ≥ 100 mg/mL (327.47 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO) H2O 中的溶解度 : 20 mg/mL (65.49 mM; 超声助溶) * “≥” means soluble, but saturation unknown. 配制储备液
查看完整储备液配制表
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
In Vivo:
请根据您的 实验动物和给药方式 选择适当的溶解方案。 以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。
动物溶解方案计算器
请输入动物实验的基本信息:
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料 |
纯度: 98.01%
Data Sheet (625 KB) SDS (251 KB)
COA (265 KB) HNMR (265 KB) LCMS (257 KB) 产品使用指南 (1538 KB) |
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参考文献 |
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