标签归档：白屈菜

Chelerythrine (Synonyms: 白屈菜红碱)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Chelerythrine  (Synonyms: 白屈菜红碱)

Chelerythrine 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性 PKC 拮抗剂，IC50 值为 0.7 μM。Chelerythrine 具有抗肿瘤、抗糖尿病、抗炎的活性。Chelerythrine 抑制 BclXL-Bak BH3 肽结合，IC50 为 1.5 μM，并从 BclXL 取代了 Bax。 Chelerythrine 诱导细胞凋亡和自噬。

Chelerythrine (Synonyms: 白屈菜红碱)

Chelerythrine Chemical Structure

CAS No. : 34316-15-9

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Chelerythrine 的其他形式现货产品:

Chelerythrine chloride

Chelerythrine 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy[3][4].

IC50 & Target[1]

PKC

0.7 μM (IC50)

体外研究
(In Vitro)

Chelerythrine (48 小时) 抑制 L-1210 细胞的生长 (IC50: 0.53 uM)[1]。
Chelerythrine (0-20 μM，24 小时) 可抑制 A549 和 NCI-H1299 细胞的细胞活力，诱导细胞凋亡和自噬[4]。
Chelerythrine (0-5 μM，24 或 48 小时) 可诱导 BclXL 过表达的 SH-SY5Y 细胞凋亡[3]。
Chelerythrine (2.5-10 μM，16 小时) 可诱导 SH-SY5Y 细胞线粒体去极化 (线粒体电位降低)，并刺激分离的线粒体释放 CytC[4]。
Chelerythrine (0-100 ng/mL，24 小时) 可减少 LPS 诱导的原代巨噬细胞中 NO 和 TNF-α 的产生[5]。
Chelerythrine (MIC: 0.156 mg/mL) 对革兰氏阳性菌、金黄色葡萄球菌 (SA)、MRSA 和超广谱 β-内酰胺酶金黄色葡萄球菌 (ESBLs-SA) 具有抗菌活性[6]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Chelerythrine 相关抗体:

Western Blot Analysis[4]

Cell Line: A549 and NCI-H1299 cells
Concentration: 10, 15, 20 μM
Incubation Time: 24 h
Result: Induced expression of LC3-II in a beclin 1-dependent way.

体内研究
(In Vivo)

Chelerythrine (5 mg/kg，腹腔注射，每日) 可减轻新生大鼠中部分单侧输尿管梗阻 (UUO) 引起的肾损伤，并恢复肾功能[2]。
Chelerythrine (1-10 mg/kg，腹腔注射，注射 100 μg/kg LPS 前 24 小时和 1 小时) 在 LPS 诱导的小鼠内毒素休克中显示出抗炎作用 (提高存活率、降低血清亚硝酸盐和 TNF-α 水平)[5]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Unilateral ureteral obstruction (UUO) induced neonatal rats[2]
Dosage: 5 mg/kg
Administration: i.p., daily
Result: Attenuated kidney injury (Increased kidney weight and restored renal function).
Inhibited UUO-induced upregulated kidney injury molecule-1 expression, apoptosis, and renal fibrosis.

分子量

348.37

Formula

C21H18NO4
CAS 号

34316-15-9
中文名称

白屈菜红碱；白屈菜赤碱
结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
初始来源
  • 植物
  • 罂粟科
  • 博落回
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (542 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.  [Content Brief]

    [2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91.  [Content Brief]

    [3]. Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6.  [Content Brief]

    [4]. Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.  [Content Brief]

    [5]. Li W, et al. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway. Inflammation. 2012 Dec;35(6):1814-24.  [Content Brief]

    [6]. He N, et al. Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam. BMC Complement Altern Med. 2018 Sep 26;18(1):261.  [Content Brief]

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