标签归档：磷酸肌醇

Glycerophosphoinositol choline (Synonyms: 甘油磷酸肌醇胆碱)

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Glycerophosphoinositol choline  (Synonyms: 甘油磷酸肌醇胆碱)

Glycerophosphoinositol choline 是一种必需营养素，可激活 α7 烟碱受体 (alpha7 nicotinic receptors)，具有镇痛、抗炎活性。可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。

Glycerophosphoinositol choline (Synonyms: 甘油磷酸肌醇胆碱)

Glycerophosphoinositol choline Chemical Structure

CAS No. : 425642-32-6

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Glycerophosphoinositol choline 的其他形式现货产品:

Choline chloride

Glycerophosphoinositol choline 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Glycerophosphoinositol choline (0 or 70 μM, 4 days) can effectively mitigate apoptosis and maintain cell viability[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Glycerophosphoinositol choline 相关抗体:

Cell Viability Assay[1]

Cell Line: Rat pheochromocytoma cells PC12
Concentration: 0 or 70 μM
Incubation Time: 4 days
Result: Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM.
Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.

体内研究
(In Vivo)

Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Postoperative pain model of female C57/Bl6 mice[2]
Dosage: 0.2 and 100 mg/kg/h
Administration: Subcutaneous injection, 24 or 48 hours
Result: Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.
Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.

Clinical Trial

分子量

437.38

Formula

C14H32NO12P
CAS 号

425642-32-6
中文名称

甘油磷酸肌醇胆碱
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (538 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. M Q Holmes-McNary, et al. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):9-16.  [Content Brief]

    [2]. T J Rowley, et al. Antinociceptive and anti-inflammatory effects of choline in a mouse model of postoperative pain. Br J Anaesth. 2010 Aug;105(2):201-7.  [Content Brief]

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