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Methicillin (Synonyms: 甲氧西林)

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Methicillin  (Synonyms: 甲氧西林)

Methicillin 是一种窄谱 β-内酰胺类抗生素，通过抑制青霉素结合蛋白 (penicillin-binding proteins, PBP) 发挥作用。Methicillin 对青霉素耐药性的金黄色葡萄球菌 Staphylococcus aureu 和表皮葡萄球菌 Staphylococcus epidermidis 有活性。Methicillin 可用于研究皮肤感染、骨髓炎和心内膜炎等疾病。

Methicillin (Synonyms: 甲氧西林)

Methicillin Chemical Structure

CAS No. : 61-32-5

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Methicillin 的其他形式现货产品:

Methicillin sodium salt

Methicillin 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

Methicillin (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Methicillin 相关抗体:
体内研究
(In Vivo)

Methicillin (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

380.42

Formula

C17H20N2O6S
CAS 号

61-32-5
中文名称

甲氧西林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (540 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.

    [2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.

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