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9-cis-Retinal (Synonyms: 9-顺式视黄醛) 纯度: ≥99.0%
9-cis-Retinal 是天然的类视黄醇。饮食中的 99-cis-β-carotene 通过裂解成 9-cis-retinoids 生成 9-cis-Retinal。9-cis-Retinal 与细胞视黄醇结合蛋白-I (CRBP-1) 和 CRBP-II 的 Kd 分别为 8 nM 和 5 nM。9-cis-Retinal 加快了视网膜类器官中杆感光细胞的分化和成熟。
9-cis-Retinal Chemical Structure
CAS No. : 514-85-2
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 1 mg | ￥1100 | In-stock | |
| 5 mg | ￥3500 | In-stock | |
| 10 mg | ￥5425 | In-stock | |
| 50 mg | 询价 | ||
| 100 mg | 询价 |
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| 生物活性 |
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with Kds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids[1][2][3]. |
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| IC50 & Target[1][2] |
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| 体外研究 (In Vitro) |
The addition of 9-cis-Retinal, instead of the widely used all-trans retinoic acid, accelerates rod photoreceptor differentiation in organoid cultures, with higher rhodopsin expression and more mature mitochondrial morphology evident by day. 9-cis-Retinal can bind opsin to form functioning rhodopsin[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
Treatment with 9-cis-retinal produced a significant recovery of the cone response in interphotoreceptor retinoid-binding protein (IRBP)-/- mice and shows that retinoid deficiency underlies cone dysfunction[4]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
284.44 |
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| Formula |
C20H28O |
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| CAS 号 |
514-85-2 |
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| 性状 |
固体 |
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| 颜色 |
Light yellow to brown |
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| 中文名称 |
9-顺式视黄醛 |
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| 结构分类 |
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| 初始来源 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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| 溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 16 mg/mL (56.25 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO) 配制储备液
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
动物溶解方案计算器
请输入动物实验的基本信息：
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
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| 纯度 & 产品资料 |
纯度: ≥99.0%
Data Sheet (600 KB) SDS (393 KB)
COA (190 KB) 元素分析报告 (207 KB) 产品使用指南 (1538 KB) |
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| 参考文献 |
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