标签归档：诃子

Chebulinic acid (Synonyms: 诃子林鞣酸)

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Chebulinic acid  (Synonyms: 诃子林鞣酸) 纯度: 99.42%

Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂，也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。

Chebulinic acid (Synonyms: 诃子林鞣酸)

Chebulinic acid Chemical Structure

CAS No. : 18942-26-2

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥6630 In-stock
1 mg ￥1700 In-stock
5 mg ￥4200 In-stock
10 mg ￥6300 In-stock
50 mg   询价  
100 mg   询价  

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Chebulinic acid 相关产品

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生物活性

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

IC50 & Target

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]
体外研究
(In Vitro)

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Chebulinic acid 相关抗体:
分子量

956.68

Formula

C41H32O27
CAS 号

18942-26-2
性状

固体

颜色

White to off-white

中文名称

诃子林鞣酸
结构分类
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 使君子科
  • 诃子
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (104.53 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0453 mL 5.2264 mL 10.4528 mL
5 mM 0.2091 mL 1.0453 mL 2.0906 mL
10 mM 0.1045 mL 0.5226 mL 1.0453 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

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体积

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.42%

Data Sheet (612 KB) SDS (393 KB)

COA (285 KB) HNMR (236 KB) LCMS (84 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Patel K et al. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action. Comput Biol Chem. 2015 Dec;59 Pt A:37-47.  [Content Brief]

    [2]. Sivasankar S et al. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acidprevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS One. 2015 Mar 20  [Content Brief]

    [3]. Mishra V et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine. 2013 Apr 15;20(6):506-11.  [Content Brief]

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