标签归档：钩藤

Hirsutine (Synonyms: 毛钩藤碱)

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Hirsutine  (Synonyms: 毛钩藤碱) 纯度: 99.46%

Hirsutine，一种 Uncaria rhynchophylla 的吲哚生物碱，具有抗癌活性。Hirsutine 诱导细胞凋亡，并且是一种有效的 Dengue virus 抑制剂，具有低毒性。

Hirsutine (Synonyms: 毛钩藤碱)

Hirsutine Chemical Structure

CAS No. : 7729-23-9

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1 mg ￥600 In-stock
5 mg ￥1600 In-stock
10 mg ￥2800 In-stock
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Hirsutine 相关产品

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生物活性

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3].

体外研究
(In Vitro)

Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Hirsutine 相关抗体:
体内研究
(In Vivo)

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

368.47

Formula

C22H28N2O3
CAS 号

7729-23-9
性状

固体

颜色

White to off-white

中文名称

毛钩藤碱； 毛帽柱木碱； 二氢柯楠因碱； 陆地棉苷
结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 植物
  • 茜草科
  • 钩藤
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (271.39 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7139 mL 13.5696 mL 27.1392 mL
5 mM 0.5428 mL 2.7139 mL 5.4279 mL
10 mM 0.2714 mL 1.3570 mL 2.7139 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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浓度

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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浓度 (final)

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体积 (final)

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给药剂量

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工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.46%

Data Sheet (603 KB) SDS (251 KB)

COA (198 KB) HNMR (262 KB) LCMS (97 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Hishiki T, et al. Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle. Front Microbiol. 2017 Aug 30;8:1674.  [Content Brief]

    [2]. Huang QW, et al. [Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway]. Sheng Li Xue Bao. 2018 Feb 25;70(1):40-46.  [Content Brief]

    [3]. Zhang R, et al. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018 May 22;9(6):598.  [Content Brief]

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