标签归档：鞣质

Cinnamtannin A2 (Synonyms: 肉桂鞣质A2)

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Cinnamtannin A2  (Synonyms: 肉桂鞣质A2)

Cinnamtannin A2 是一种四聚体原花青素，可以增加小鼠的 GLP-1 和胰岛素分泌。Cinnamtannin A2 可以上调促肾上腺皮质激素释放激素的表达。Cinnamtannin A2 具有抗氧化，抗糖尿病和肾保护作用。

Cinnamtannin A2 (Synonyms: 肉桂鞣质A2)

Cinnamtannin A2 Chemical Structure

CAS No. : 86631-38-1

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Cinnamtannin A2 相关产品

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生物活性

Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect[1][2].

体外研究
(In Vitro)

Cinnamtannin A2 (0.125-2.0 μg/mL) inhibits LDL oxidation induced by copper ions or MeO-AMVN[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cinnamtannin A2 相关抗体:
体内研究
(In Vivo)

Cinnamtannin A2 (10 mg/kg; i.p. for 30 days) ameliorates the level of KIM1 and NAGL in 5/6 nephractomized rats by regulating Nrf2- Keap1 pathway[2].
Cinnamtannin A2 (10 μg/kg; p.o.) increases the secretion of insulin and glucagon-like peptide-1 (GLP-1) in plasma of mice[1].
Cinnamtannin A2 (10 μg/kg; p.o.) significantly promotes phosphorylation of both IRB and IRS-1 in mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) were induced chronic renal failure (CRF) by removing the kidneys[2]
Dosage: 10 mg/kg
Administration: I.p. for 30 days
Result: Ameliorated the altered level of creatinine, blood urea nitrogen, Neutrophil gelatinase-associated lipocalin, Kidney Injury Molecule-1 and cytokines in the serum and microalbuminurea.
Reduced the oxidative stress level.
Attenuated the altered expression of proteins involved in Nrf2-Keap1 pathway in the kidney tissue.
Reduced the tubular injury score in the kidney tissue.

分子量

1155.02

Formula

C60H50O24
CAS 号

86631-38-1
中文名称

肉桂鞣质A2
结构分类
  • Flavonoids
  • Flavanonols
  • Flavonoids
  • Biflavones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 樟科
  • 肉桂
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (541 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Yamashita Y, et, al. Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 and insulin secretion in mice. Biosci Biotechnol Biochem. 2013;77(4):888-91.  [Content Brief]

    [2]. Li N, et, al. Cinnamtannin A2 protects the renal injury by attenuates the altered expression of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression in 5/6 nephrectomized rat model. AMB Express. 2020 May 8;10(1):87.  [Content Brief]

    [3]. Osakabe N, et, al. Catechins and their oligomers linked by C4 –> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp Biol Med (Maywood). 2002 Jan;227(1):51-6.  [Content Brief]

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